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Objective To discuss the eradication effect and application value of quad solution containing bismuth agent in the treatment of helicobacter pylori.Methods 210 patients with helicobacter pylori infection were selected.The patients were randomly divided into three groups A,B,C,respectively,and the three group were given three different bismuth agent quadruple therapy.Group A received furazolidone, tetracycline and rabeprazole joint colloidal bismuth pectin capsules;Group B received amoxicillin and levofloxacin, rabeprazole joint colloidal bismuth pectin capsules;Group C received furazolidone, amoxicillin and rabeprazole joint colloidal bismuth pectin capsules. The treatment effect was recorded.Results There were 2,4,3 cases in A,B,C groups lost to follow-up,including 12 cases in group A positive review,positive review of 11 cases of group B,group C positive review of 13 cases,the therapeutic effect among three groups had no statistically significant difference (P>0.05).The total cost,eradication rate and C/E of group A were 198.38 yuan,82.35%,240.90,which of group B were 479.92 yuan,83.33%, 575.93,which of group C were 280.98 yuan,80.60%,348.61.C/E of group A had the most economic advantage. Conclusion Tetracycline or amoxicillin combined furazolidone, levofloxacin combined amoxicillin quad solution containing bismuth agent can be used as an effective method to the eradication of helicobacter pylori,but the tetracy-cline,furazolidone quadruple scheme through more continue to advantage,more suitable for popularization and applica-tion in clinic.
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This paper is to report the investigation on the metabolic behavior of Staphylococcus aureus (S. aureus) after given Qingkailing injection, and with the aim of seeking for a new quality control method based on biological assessment. The growth thermogenic curves of S. aureus were determined by microcalorimetry and analyzed by computer. The results showed that in the concentration range of (0-5.00%), the growth thermogenic curves of S. aureus were declined and removed back with increasing dosage of Qingkailing injection; the main parameters (T1, T2, k1, P1, P2 and I) and the dosage of Qingkailing injection have good correlation. The 50% inhibiting dosage is 3.26 %, and the optimal inhibiting dosage is 5.47%. Difference could be detected among the Qingkailing injection samples from different factories and different batches. It is proved that Qingkailing injection could inhibit the metabolic behavior of S. aureus, and microcalorimetry might be applied in the quality assessment of Qingkailing injection.
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The inhibitory ratio (1%) of artificial musk on cyclooxygenase-2 (COX-2) was determined by enzyme immunoassay (EIA). The dose-effect relationship between concentrations of artificial musk and 1% was established. It was found that artificial musk had obvious inhibitory action on COX-2. The concentration for 50% of maximum inhibitory effect (IC50) was about 2.26 mg x mL(-1). There was a good relationship between the logarithm concentrations of artificial musk and 1% when the concentrations of artificial musk ranged from 0.31-20.0 mg x mL(-1). The results indicated that this EIA method could be applied to evaluate the anti-inflammatory activity of artificial musk quickly, conveniently, sensitively and exactly. This paper provided a novel method and foundational research for the bioassay of artificial musk.
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Objective To explore the effect of transcatheter hepatic artery chemoembolization(TACE)between different types of liver cancer patients with portal vein tumor thrombus(PVTT).Methods 413 liver cancer patients with PVTT were divided into two groups,TACE(332 cases)group and control group(81 cases);To compare the survival rate and the curative effect of two group.Results Survival rate in the TACE group of 3 months,6 months,12 months,24 months were 93.4%,71.7%,44.9%,24.4%,in the control group 3 months,6 months,12 months,24 months survival rate were 24.7%,2.5%,0,0.The difference has statistical significance(P＜0.01).In the TACE group,type Ⅰ,Ⅱ,Ⅲ,Ⅳ of PVTT patients treatmented with TACE also has different survival rate and different curative effect(P＜0.01).Conclusion TACE treatment is particularly effective for type Ⅰ,type Ⅱ and type Ⅲ patients of PVTT.
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Objective To study the distribution of hepatitis B virus genotype and subgenotype in Handan and clarify the genotype-related difference in clinic.Methods PCR-RFLP was used to detect the HBV genotype and subgenotype in 108 HBV-infected patients from Handan Infectious Disease Hospital from January,2006 to April,2006.Analyze the correlation of HBV genotype and clinical characteristicly of patients.Results Among 108 HBV-infected patients,the proportion of genotype B and C is 6.5% and 93.5% respectively.All genotype B patients were subgenotype Ba.In genotype C group,88.1% was subgenotype C2;genotype distribution showed no significant difference between male and female.ALT and AST level were higher in genotype C group than those in genotype B group.Conclusion HBV genotype C is predominant in chronic hepatitis B patients in Handan city.HBV subgenotype C2 is the major subgenotype in Handan city.The positive rate of HBeAg and HBV DNA levels are higher in genotype C than those in genotype B group.Genotype C and genotype B have no difference in the severity of liver disease and HBV-DNA.associated with.Clinical feature of subgenotype C1 and subgenotype C2 is similar.
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0 05).The size of PEI group was larger than that of PAI group 2 months after treatment (P